Vistara Single-Gene Non-Invasive Prenatal Test (NIPT)

The Vistara prenatal single-gene blood screening test is offered at MUMS – for serious genetic conditions. Vistara tests for 25 genetic conditions.

• Testing from 9 weeks of pregnancy
• Results take approx. 3 weeks
• Vistara, single-gene NIPT, - insights for better health outcomes

Genes are sections of DNA which guide how our cells function and grow. Some genetic conditions are caused by chance when a change happens in a specific gene in an egg or sperm.

Single-gene conditions can impact a developing baby’s – bones, heart, brain, and skull.

Vistara is available for singleton pregnancies, including egg donor and gestational carrier pregnancies.

NIPT Panorama and Illumina screens for large genetic changes such as Downs, Edwards, Patau whereas Vistara single-gene screens offers additional insights about your baby’s health from the placental DNA for signs of single-gene changes – for example –genetic conditions relating to the heart, bones, brains, skull. Full list below.

Positive Vistara results

• Remote consult with MUMS consultant to explain the result
• Remote Genetic Counselling is available with the Geneticist at the laboratory
• The option to have a detailed scan and consultation with a Consultant in Fetal Medicine
• Invasive Testing – CVS or Amniocentesis

1 in 600 pregnancies are affected by a single-gene condition which are more common than Down Syndrome. Children can benefit from early treatment.

If the test is inconclusive, no result - You have the option to have the test repeated at no extra cost. Approximately 1 in 25 tests could result in either no result or “other type of result”.

Early insights guide healthier futures

• Screens for 25 autosomal dominant and X-linked conditions across 30 genes with Vistara single-gene NIPT
• Combined incidence greater than Down syndrome
• Provide clinically actionable information
• Many single-gene conditions benefit from early intervention
• Inform decisions for pregnancy and delivery management, early interventions, and patient education to ensure every child reaches their full potential
• Perform testing with ease and get clear results
• No paternal and/or egg-donor sample necessary
• Find conditions other screening modalities would miss until after the window for critical intervention

Why have the Vistara Single Gene Test in addition to Panorama or Illumina?

• Couples with a male partner >40years of age
• Increased Nuchal Results
• Abnormal ultrasound findings
• Short bones found on Ultrasound
• Family history of hereditary conditions that are screened in Vistara
• Patients who want all information that is available through prenatal testing – non-invasively
• Prenatal Genetic Counselling available
• 99% sensitivity and 99% specificity
• Confident pregnancy management and early interventional decisions

As with Panorama and Illumina NIPT– Vistara Single Gene NIPT is a screening test and not a diagnostic test. If positive – the pregnancy may be affected by the positive screen for one of the conditions. Invasive diagnostic tests  - Amniocentesis and CVS may be recommended.

Vistara Single Gene screens for 25 genetic conditions - across 30 genes:

• Achondroplasia – FGFR3
• Alagille Syndrome – JAG1
• Antley Bixler Syndrome – FGFR2
• Apert Syndrome – FGFR2
• Cardiofaciocutaneous Syndrome 1,3,4 – BRAF, MAP2K1, MAP2K2
• CATSHL Syndrome – FGFR3
• CHARGE Syndrome - CHD7
• Cornelia de Lange Syndrome 1,2,3,4,5 – NIPBL, SMC1A, SMC3, RAD21, HDAC8
• Costello Syndrome – HRAS
• Crouzon Syndrome – FGFR2, FGFR3
• Ehlers-Danlos Syndrome, classic, type VIIA, cardiac valvular form, type VIIB – COL1A1, COL1A2
• Epileptic encephalopathy, early infantile, 2 – CDKL5
• Hypochondroplasia - FGFR3
• Intellectual disability – SYNGAP1
• Jackson Weiss Syndrome – FGFR2
• Juvenile Myelomonocytic Leukaemia (JMML) – PTPN11
• LEOPARD Syndrome 1,2 (Noonan Syndrome with multiple lentigines) PTPN11, RAF1
• Muenke Syndrome – FGFR3
• Noonan syndrome 1,3,4,5,6,8,9 – PTPN11, SOS1, RAF1, RIT1, KRAS, NRAS, SOS2, SHOC2, BRAF, MAP2K1, HRAS, CBL
• Osteogenesis Imperfecta, type 1,11,1V – COL1A1, COL1A2
• Pfeiffer Syndrome type 1,2,3 – FGFR2
• Rett Syndrome – MECP2
• Sotos Syndrome 1 – NSD1
• Thanatophoric dysplasia, type 1,11 – FGFR3
• Tuberous Sclerosis 1,2 – TSC1, TSC2

The scan associated with Vistara screening simply confirms baby’s heartbeat and gestation.

This scan associated with Vistara NIPT is not for:

• Gender 
• Reassurance
• Fetal Development
• Anatomy/anomaly
• Growth and well-being 

However – for ladies who are beyond 12 weeks wanting Vistara and a scan for more than just clarification of gestation and heartbeat then book one of the scans above with your NIPT/NIPT Single Gene test as an add on.

Cost of test is £925 including ultrasound scan and follow up consultation with results – or £885 if Vistara is tested at the same time as your NIPT Panorama or Illumina.

If you are interested in having Vistara in addition to your NIPT Test – call us on 0121 704 2669 or email us – administrator@mums.me.uk.

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